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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Cytosine arabinoside - Aracytine - Cytarabine - Ara-C

3

II.a Pulmonary edema, noncardiogenic (NCPE)

3
Last update : 29/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Cytarabine induced noncardiogenic pulmonary edema in a case of acute lymphoblastic leukemia.
International journal of laboratory hematology 2007 Dec;29;482-3 2007 Dec
[Pulmonary complications of induction therapy in acute myeloid leukemia in adults. Findings in chest x-rays and computer tomography].
Aktuelle Radiologie 1998 Mar;8;87-94 1998 Mar
Pulmonary insufficiency complicating therapy with high dose cytosine arabinoside in five pediatric patients with relapsed acute myelogenous leukemia.
Cancer 1994 Oct 01;74;1953-8 1994 Oct 01
Pulmonary edema and shock after high-dose aracytine-C for lymphoma; possible role of TNF-alpha and PAF.
European cytokine network 1993;4;147-51 1993
Fatal pulmonary failure complicating high-dose cytosine arabinoside therapy in acute leukemia.
Cancer 1990 Mar 01;65;1079-84 1990 Mar 01
Prolonged high dose ARA-C infusions in acute leukemia.
Leukemia 1988 May;2;304-6 1988 May
Non-cardiogenic pulmonary edema complicating intermediate and high-dose Ara C treatment for relapsed acute leukemia.
Medical oncology and tumor pharmacotherapy 1988;5;41-7 1988
Pulmonary complications of cytosine-arabinoside therapy: radiographic findings.
AJR. American journal of roentgenology 1987 Jul;149;23-7 1987 Jul
Ara-C lung: noncardiogenic pulmonary edema complicating cytosine arabinoside therapy of leukemia.
The American journal of medicine 1981 Feb;70;256-61 1981 Feb

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