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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Rituximab-CHOP regimen (R-CHOP)

2

I.b Pneumonitis (ILD)

1
Last update : 04/12/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Rituximab-induced pneumonitis mimicking miliary tuberculosis.
European respiratory review : an official journal of the European Respiratory Society 2013 Dec;22;587-8 2013 Dec
A case of interstitial pneumonia induced by rituximab therapy.
International journal of hematology 2005 Feb;81;169-70 2005 Feb
Interstitial pneumonitis related to rituximab therapy.
The New England journal of medicine 2003 Jun 26;348;2690-1; discussion 2690-1 2003 Jun 26

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