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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nivolumab

5

X.j Myopathy-Myositis-Polymyositis (see also under Xba)

1
Last update : 20/10/2016
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Avelumab
1
Durvalumab
3
Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx
5
Lambrolizumab
4
PD-1/PD-L1-inhibitors or blocking agents/drugs
5
Pembrolizumab
5

Publications

Nivolumab-associated myositis myocarditis and myasthenia and anti-striated muscle antibodies.
Internal medicine journal 2020 Aug;50;1003-1006 2020 Aug
Nivolumab-related myasthenia gravis with myositis and myocarditis in Japan.
Neurology 2017 Sep 12;89;1127-1134 2017 Sep 12
[Unexpected adverse events of immunotherapies in non-small cell lung cancer: About 2 cases].
Revue de pneumologie clinique 2017 Dec;73;326-330 2017 Dec
Nivolumab-Induced Myocarditis Concomitant with Myasthenia Gravis.
Case reports in oncology 2017;10;809-812 2017
Myasthenic crisis and polymyositis induced by one dose of nivolumab.
Cancer science 2016 Jul;107;1055-8 2016 Jul
Acetylcholine receptor binding antibody-associated myasthenia gravis and rhabdomyolysis induced by nivolumab in a patient with melanoma.
Japanese journal of clinical oncology 2016 Jan;46;86-8 2016 Jan
Case of respiratory discomfort due to myositis after administration of nivolumab.
The Journal of dermatology 2015 Oct;42;1008-9 2015 Oct

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