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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nivolumab

5

XV.c Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)

1
Last update : 11/08/2016
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Avelumab
1
Durvalumab
3
Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx
5
Lambrolizumab
4
PD-1/PD-L1-inhibitors or blocking agents/drugs
5
Pembrolizumab
5

Publications

Non-neoplastic inflammatory pseudotumor of the lung after immunotherapy for melanoma: A diagnostic pitfall on fine needle aspiration biopsy of lung.
Diagnostic cytopathology 2021 Oct;49;1150-1154 2021 Oct
Mesalazine-induced Bronchiolitis Obliterans With Organising Pneumonia in a Young Patient With Ulcerative Colitis.
Journal of Crohn's & colitis 2018 Nov 15;12;1377-1378 2018 Nov 15
Melanoma patient response to nivolumab treatment for metastatic lung lesions: Multi-OMICS analysis in Project HOPE.
The Journal of dermatology 2017 Oct;44;1156-1159 2017 Oct
Late-occurring nivolumab-induced cryptogenic organising pneumonia mimicking lung progression in a patient with metastatic non-small cell lung cancer.
European journal of cancer (Oxford, England : 1990) 2017 Nov;85;155-157 2017 Nov
Nivolumab-induced organizing pneumonia in a melanoma patient.
Japanese journal of clinical oncology 2016 Mar;46;270-2 2016 Mar
Organizing Pneumonia Induced by Nivolumab in a Patient with Metastatic Melanoma.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2016 Mar;11;432-3 2016 Mar

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