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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nivolumab

5

I.d Organizing pneumonia pattern (an area or areas of consolidation on imaging)

1
Last update : 11/08/2016
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Avelumab
1
Durvalumab
3
Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx
5
Lambrolizumab
4
PD-1/PD-L1-inhibitors or blocking agents/drugs
5
Pembrolizumab
5

Publications

Non-neoplastic inflammatory pseudotumor of the lung after immunotherapy for melanoma: A diagnostic pitfall on fine needle aspiration biopsy of lung.
Diagnostic cytopathology 2021 Oct;49;1150-1154 2021 Oct
Late-occurring nivolumab-induced cryptogenic organising pneumonia mimicking lung progression in a patient with metastatic non-small cell lung cancer.
European journal of cancer (Oxford, England : 1990) 2017 Nov;85;155-157 2017 Nov
Nivolumab-induced organizing pneumonitis in a patient with lung sarcomatoid carcinoma.
Lung cancer (Amsterdam, Netherlands) 2016 Sep;99;162-5 2016 Sep
Nivolumab-induced organizing pneumonia in a melanoma patient.
Japanese journal of clinical oncology 2016 Mar;46;270-2 2016 Mar

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