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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nivolumab

5

X.g Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

3
Last update : 20/10/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Avelumab
1
Durvalumab
3
Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx
5
Lambrolizumab
4
PD-1/PD-L1-inhibitors or blocking agents/drugs
5
Pembrolizumab
5

Publications

Exploring novel immune-related toxicities and endpoints with immune-checkpoint inhibitors in non-small cell lung cancer.
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting 2013;; 2013
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.
The New England journal of medicine 2012 Jun 28;366;2455-65 2012 Jun 28

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