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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Vemurafenib

1

I.m ILD with a granulomatous component

1
Last update : 08/03/2020
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Relapsing pneumonitis due to two distinct inhibitors of the MAPK/ERK pathway: report of a case.
BMC cancer 2015 Oct 19;15;732 2015 Oct 19

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