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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Vemurafenib

1

I.ad Radiation recall pneumonitis

1
Last update : 21/04/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Radiation recall dermatitis and radiation pneumonitis during treatment with vemurafenib.
Melanoma research 2014 Oct;24;512-6 2014 Oct
Increased skin and mucosal toxicity in the combination of vemurafenib with radiation therapy.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 2014 Nov;190;1169-72 2014 Nov

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