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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Cyclosporine

2

X.c Capillary leak syndrome (CLS)

1
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Pulmonary capillary leak syndrome with intravenous cyclosporin A in pediatric renal transplantation.
Pediatric transplantation 2000 Feb;4;35-8 2000 Feb
Pulmonary capillary leak syndrome associated with the use of intravenous cyclosporin.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1996 Nov;11;2342-3 1996 Nov
Disappearance of pulmonary capillary leak syndrome when intravenous cyclosporine is replaced by oral cyclosporine.
Transplantation 1987 May;43;758-9 1987 May

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