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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Cyclosporine

2

II.b ARDS - Acute lung injury

1
Last update : 15/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Cyclosporine and adult respiratory distress syndrome.
Transplantation 1988 Nov;46;776-7 1988 Nov
Adult respiratory distress syndrome associated with oral cyclosporine.
Transplantation 1987 May;43;767-8 1987 May
Adult respiratory distress syndrome following intravenous cyclosporine.
Clinical transplants 1986;;128 1986
Adult respiratory distress syndrome and convulsions associated with administration of cyclosporine in liver transplant recipients.
Transplantation 1984 Oct;38;341-3 1984 Oct

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