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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Neuromuscular blocking agents (NMBA-NMBD)
5
IV.a
Bronchospasm - Wheezing - Asthma
2
Last update :
12/01/2015
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Cisatracurium
Curares
Rocuronium
Vecuronium
Publications
Anaphylactic bronchospasm during general anesthesia is not related to asthma.
Mivacurium and bronchospasm.
Rapacuronium and the risk of bronchospasm in pediatric patients.
Severe bronchospasm and desaturation in a child associated with rapacuronium.