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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Neuromuscular blocking agents (NMBA-NMBD)

5

IV.a Bronchospasm - Wheezing - Asthma

2
Last update : 12/01/2015
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Cisatracurium
1
Curares
5
Rocuronium
1
Vecuronium
2

Publications

Anaphylactic bronchospasm during general anesthesia is not related to asthma.
Allergy 2015 Apr;70;453-6 2015 Apr
Mivacurium and bronchospasm.
Anesthesia and analgesia 2003 Aug;97;484-485 2003 Aug
Rapacuronium and the risk of bronchospasm in pediatric patients.
Anesthesia and analgesia 2002 Mar;94;488-93; table of contents 2002 Mar
Severe bronchospasm and desaturation in a child associated with rapacuronium.
Anesthesiology 2001 May;94;923-4 2001 May

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