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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Contraceptive drugs or pills (oral)

3

VI.a Pulmonary embolism - Venous thrombosis/thromboembolism

3
Last update : 09/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Pulmonary embolism due to exogenous estrogen intoxication.
The American journal of emergency medicine 2017 Dec;35;1984.e1-1984.e2 2017 Dec
Combined oral contraceptives: venous thrombosis.
The Cochrane database of systematic reviews 2014 Mar 03;2014;CD010813 2014 Mar 03
Thromboembolic events in women exposed to hormonal contraception or cyproterone acetate in 2012: a cross-sectional observational study in 30 French public hospitals.
Drug safety 2014 Apr;37;269-82 2014 Apr
Venous thromboembolism in women taking hormonal contraceptives.
Expert review of cardiovascular therapy 2010 Feb;8;211-5 2010 Feb
Oral contraceptives and the absolute risk of venous thromboembolism in women with single or multiple thrombophilic defects: results from a retrospective family cohort study.
Archives of internal medicine 2007 Feb 12;167;282-9 2007 Feb 12
Pulmonary embolism associated with combined oral contraceptives: reporting incidences and potential risk factors for a fatal outcome.
Acta obstetricia et gynecologica Scandinavica 2004 Jun;83;576-85 2004 Jun
Oral contraceptives and the risk of venous thrombosis.
The New England journal of medicine 2001 May 17;344;1527-35 2001 May 17

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