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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Colchicine

1

II.b ARDS - Acute lung injury

1
Last update : 02/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Multiple organ failure after an overdose of less than 0.4 mg/kg of colchicine: role of coingestants and drugs during intensive care management.
Clinical toxicology (Philadelphia, Pa.) 2010 Oct;48;845-8 2010 Oct
[Acute respiratory distress syndrome in adults in colchicine poisoning].
Annales francaises d'anesthesie et de reanimation 1986;5;530-2 1986
Letter: Adult respiratory distress syndrome associated with colchicine intoxication.
Annals of internal medicine 1975 Oct;83;523-4 1975 Oct

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