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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Golimumab

1

X.s Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

1
Last update : 01/06/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
TNF-alpha antagonists / inhibitors
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Publications

Onset of Wegener's granulomatosis during therapy with golimumab for rheumatoid arthritis: a rare adverse event?
Rheumatology (Oxford, England) 2010 Sep;49;1785-7 2010 Sep

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