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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Taxanes

4

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

2
Last update : 17/03/2022
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Docetaxel
3
Paclitaxel
5

Publications

Taxane-induced acute interstitial pneumonitis in patients with breast cancer and outcome of taxane rechallenge.
Lung India : official organ of Indian Chest Society 2022;39;158-168 2022

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