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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Citrate anticoagulant

1

VI.v Foreign body/substance pulmonary embolism

1
Last update : 04/03/2018
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Trisodium citrate induced protein precipitation in haemodialysis catheters might cause pulmonary embolism.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012 Jul;27;2953-7 2012 Jul
Embolic complications from central venous hemodialysis catheters used with hypertonic citrate locking solution.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2010 Feb;55;348-51 2010 Feb

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