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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Clopidogrel

2

V.e Hemothorax - Serosanguineous pleural effusion

1
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Clopidogrel increases bleeding complications in patients undergoing heart rhythm device procedures.
Pacing and clinical electrophysiology : PACE 2012 May;35;605-11 2012 May
[Pulmonary haemorrhage and haemothorax after massive ingestion of clopidogrel as a suicide attempt].
Archivos de bronconeumologia 2009 Nov;45;570-1 2009 Nov
[Bilateral hemothorax secondary to combined antiplatelet therapy with clopidogrel and acetylsalicylic acid].
Archivos de bronconeumologia 2006 Jun;42;307-9 2006 Jun
A feasibility study of the safety and efficacy of a combined clopidogrel and aspirin regimen following off-pump coronary artery bypass grafting.
The heart surgery forum 2003;6;288-91 2003

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