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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Organophosphates

5

II.b ARDS - Acute lung injury

2
Last update : 21/12/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Malathion
1

Publications

Organophosphorus Poisoning: Acute Respiratory Distress Syndrome (ARDS) and Cardiac Failure as Cause of Death in Hospitalized Patients.
International journal of molecular sciences 2023 Apr 03;24; 2023 Apr 03
Respiratory complications of organophosphorus nerve agent and insecticide poisoning. Implications for respiratory and critical care.
American journal of respiratory and critical care medicine 2014 Dec 15;190;1342-54 2014 Dec 15

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