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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Clofazimine

1

XV.u Path: Crystal storage disease

1
Last update : 08/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Fatal course of clofazimine-induced pulmonary crystal deposition in a patient with Melkersson-Rosenthal syndrome.
International journal of clinical pharmacology and therapeutics 2020 Sep;58;518-522 2020 Sep
Pulmonary clofazimine crystals in two patients with the acquired immunodeficiency syndrome.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 1997 Feb;1;88-9 1997 Feb
[Reversible pulmonary overload with clofazimine (Lamprene) in HIV-positive subjects].
Annales de pathologie 1995;15;224-5 1995

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