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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Gases
5
VII.h
Pneumomediastinum
1
Last update :
12/08/2015
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Amyl-nitrite, butyl-nitrite, isobutyl-nitrite ('Poppers')
Antidotes
Carbon dioxide (CO2)
Carbon monoxide (CO)
Chemicals
Chlorine gas (dichlorine: Cl2)
Inhalants (volatile substances)
Inhaled anesthetic agents
Methyl bromide
Nitric oxide (NO)
Oxygen (dioxygen, O2)
Propane
Riot control agents (RCA)
Sulfur mustard (mustard gas)
Publications
Pneumomediastinum from acute inhalation of chlorine gas in 2 young patients.