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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Gases

5

IV.q Reactive airway dysfunction syndrome (RADS)

3
Last update : 01/11/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Amyl-nitrite, butyl-nitrite, isobutyl-nitrite ('Poppers')
4
Antidotes
1
Carbon dioxide (CO2)
2
Carbon monoxide (CO)
5
Chemicals
5
Chlorine gas (dichlorine: Cl2)
5
Inhalants (volatile substances)
5
Inhaled anesthetic agents
3
Methyl bromide
1
Nitric oxide (NO)
4
Oxygen (dioxygen, O2)
4
Propane
1
Riot control agents (RCA)
5
Sulfur mustard (mustard gas)
3

Publications

Chlorine gas release associated with employee language barrier--Arkansas, 2011.
MMWR. Morbidity and mortality weekly report 2012 Dec 07;61;981-5 2012 Dec 07
Long-term pathologic consequences of acute irritant-induced asthma.
The Journal of allergy and clinical immunology 2009 Nov;124;975-81.e1 2009 Nov

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