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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Vildagliptin

2

VIII.a Angioedema (may cause UAO, asphyxia and death)

2
Last update : 11/05/2015
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Gliptins
2
Sitagliptin
1

Publications

Angiotensin-converting enzyme and dipeptidyl peptidase IV inhibitors: an increased risk of angioedema.
Hypertension (Dallas, Tex. : 1979) 2009 Sep;54;468-70 2009 Sep
Dipeptidyl peptidase-IV inhibitor use associated with increased risk of ACE inhibitor-associated angioedema.
Hypertension (Dallas, Tex. : 1979) 2009 Sep;54;516-23 2009 Sep

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