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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Trandolapril

1

VIII.a Angioedema (may cause UAO, asphyxia and death)

1
Last update : 22/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Angiotensin converting enzyme inhibitors (ACEI)
5

Publications

ACEI associated angioedema - a case study and review.
Australian family physician 2011 Dec;40;985-8 2011 Dec
Angioedema may not be a class side-effect of the angiotensin-converting-enzyme inhibitors.
QJM : monthly journal of the Association of Physicians 2006 Mar;99;197-8 2006 Mar

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