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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Chlorpropamide

1

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

1
Last update : 24/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Chlorpropamide-induced pulmonary infiltration and eosinophilia with multisystem toxicity.
Journal of the Tennessee Medical Association 1986 Feb;79;82-4 1986 Feb
Pulmonary infiltration eosinophilia with chlorpropamide therapy.
Southern medical journal 1984 Dec;77;1615 1984 Dec
Possible pulmonary reaction to chlorpropamide.
The New England journal of medicine 1977 Apr 21;296;945-6 1977 Apr 21
PULMONARY INFILTRATION WITH EOSINOPHILS CAUSED BY CHLORPROPAMIDE.
Lancet (London, England) 1964 Jun 06;1;1249-50 1964 Jun 06

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