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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Radiation therapy, stereotactic (SBRT)

5

I.y Progression, acceleration or exacerbation of preexisting ILD/fibrosis

1
Last update : 10/11/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Radiation therapy (early effects)
5
Radiation therapy (medium term & late effects)
5
Radiation therapy to the chest
5

Publications

Impact of pretreatment interstitial lung disease on radiation pneumonitis and survival after stereotactic body radiation therapy for lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2015 Jan;10;116-25 2015 Jan
Acute exacerbation of subclinical idiopathic pulmonary fibrosis triggered by hypofractionated stereotactic body radiotherapy in a patient with primary lung cancer and slightly focal honeycombing.
Radiation medicine 2008 Oct;26;504-7 2008 Oct

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