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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Anorexigens - Anorectic agents - Appetite suppressants

4

VI.b Pulmonary arterial hypertension

4
Last update : 16/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Aminorex
5
Cannabinoids - Cannabinoid receptor agonists (synthetic) (K2, Spice)
5
Dexfenfluramine
3
Dinitrophenol (2, 4-dinitrophenol or DNP)
3
Fenfluramine
3
Levamisole
4
Mazindol
1
Phentermine
3
Thyroid hormones (exogenous)
1

Publications

Changing demographics, epidemiology, and survival of incident pulmonary arterial hypertension: results from the pulmonary hypertension registry of the United Kingdom and Ireland.
American journal of respiratory and critical care medicine 2012 Oct 15;186;790-6 2012 Oct 15
Pulmonary arterial hypertension in a patient with Cowden syndrome and anorexigen exposure.
Chest 2011 Oct;140;1066-1068 2011 Oct
Pulmonary arterial hypertension associated with fenfluramine exposure: report of 109 cases.
The European respiratory journal 2008 Feb;31;343-8 2008 Feb
Anorexigens and pulmonary hypertension in the United States: results from the surveillance of North American pulmonary hypertension.
Chest 2000 Mar;117;870-4 2000 Mar
Primary pulmonary hypertension and anorectic drugs.
The New England journal of medicine 1999 Feb 11;340;480-2 1999 Feb 11
Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension.
Circulation 1999 Aug 24;100;869-75 1999 Aug 24
Primary pulmonary hypertension associated with the use of fenfluramine derivatives.
Chest 1998 Sep;114;195S-199S 1998 Sep
[Development of pulmonary hypertension and multi-valvular damage caused by appetite depressants].
Harefuah 1998 Dec 01;135;489-92, 568 1998 Dec 01
High incidence of primary pulmonary hypertension associated with appetite suppressants in Belgium.
The European respiratory journal 1998 Aug;12;271-6 1998 Aug
Aminorex, dexfenfluramine, and primary pulmonary hypertension.
Journal of clinical epidemiology 1998 Apr;51;361-4 1998 Apr
Appetite-suppressant drugs and the risk of primary pulmonary hypertension. International Primary Pulmonary Hypertension Study Group.
The New England journal of medicine 1996 Aug 29;335;609-16 1996 Aug 29

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