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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Radiation therapy, infusional (injected 131I or 90Y radioactivity)

2

I.o Focal/localized area of pneumonitis/fibrosis

1
Last update : 15/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Incidence of radiation pneumonitis after hepatic intra-arterial radiotherapy with yttrium-90 microspheres assuming uniform lung distribution.
American journal of clinical oncology 2008 Oct;31;431-8 2008 Oct
Radiation pneumonitis caused by yttrium-90 microspheres: radiologic findings.
AJR. American journal of roentgenology 1994 Jun;162;1300-2 1994 Jun

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