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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Chlorpromazine

2

X.b Antiphospholipid antibodies w/wo the APL syndrome

1
Last update : 04/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Chlorpromazine-associated antiphospholipid antibody syndrome.
The Annals of pharmacotherapy 2007 Mar;41;528 2007 Mar
Plasmapheresis for a schizophrenic patient with drug-induced lupus anti-coagulant.
The Journal of international medical research 1996;24;147-50 1996

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