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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Chlorpromazine

2

X.d Lupus - Lupus syndrome (see also Vd)

1
Last update : 04/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Drug-induced lupus erythematosus.
Autoimmunity 2005 Nov;38;507-18 2005 Nov
Chlorpromazine-induced lupus with cardiac tamponade.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 1995 Feb;1;60-2 1995 Feb
Drug-induced lupus.
Drug safety 1995 Apr;12;283-90 1995 Apr
Left pulmonary artery thrombosis in chlorpromazine-induced lupus.
Chest 1990 Dec;98;1545 1990 Dec

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