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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Ipratropium

1

IV.a Bronchospasm - Wheezing - Asthma

1
Last update : 12/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Review of ipratropium bromide in induced bronchospasm in patients with asthma.
The American journal of medicine 1986 Nov 14;81;36-44 1986 Nov 14
Bronchoconstriction induced by ipratropium bromide in asthma: relation to hypotonicity.
British medical journal (Clinical research ed.) 1984 Aug 25;289;469 1984 Aug 25

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