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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Chlorozotocin (DCNU)

1

I.b Pneumonitis (ILD)

1
Last update : 17/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Pulmonary complications of novel antineoplastic agents for solid tumors.
Chest 2008 Feb;133;528-38 2008 Feb
Combination chemotherapy pneumonitis: a case report of possible synergistic toxicity.
Medical and pediatric oncology 1983;11;116-8 1983
Pulmonary disease as a complication of chlorozotocin chemotherapy.
Cancer treatment reports 1981;65;223-9 1981

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