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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Chloroquine

3

IX.a Diaphragm/inspiratory muscle weakness/paralysis (w/wo ARF)

1
Last update : 26/03/2015
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Hydroxychloroquine
3
Malaria prophylaxis
2
Mefloquine
1

Publications

42-year-old man with discoid lupus and progressive weakness.
Brain pathology (Zurich, Switzerland) 2009 Jan;19;153-6 2009 Jan
Hydroxychloroquine-induced toxic myopathy causing respiratory failure.
Chest 2007 Feb;131;588-90 2007 Feb
Respiratory failure associated with hydroxychloroquine neuromyopathy.
European neurology 1995;35;236-7 1995

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