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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Chloroquine

3

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

2
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Hydroxychloroquine
3
Malaria prophylaxis
2
Mefloquine
1

Publications

A rare cause of acute respiratory failure and elevated eosinophils in broncho-alveolar lavage fluid.
Respiration; international review of thoracic diseases 2009;77;224-8 2009
Mefloquine-induced eosinophilic pneumonia.
Pharmacotherapy 2007 Dec;27;1767-71 2007 Dec
[Chloroquine-induced drug hypersensitivity alveolitis].
Pneumologie (Stuttgart, Germany) 2000 Sep;54;395-7 2000 Sep
Pulmonary infiltrates with masto- and lymphocytosis in BALF associated with arechine.
Polish journal of pathology : official journal of the Polish Society of Pathologists 1997;48;63-7 1997
Pulmonary toxicity of malaria prophylaxis.
BMJ (Clinical research ed.) 1988 Nov 12;297;1240-1 1988 Nov 12

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