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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Radiation therapy to the breast

4

XII.o Coronary artery disease (subacute, chronic)

3
Last update : 16/05/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Radiation therapy (early effects)
5
Radiation therapy (medium term & late effects)
5

Publications

Incidence of heart disease in 35,000 women treated with radiotherapy for breast cancer in Denmark and Sweden.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2011 Aug;100;167-75 2011 Aug
Long-term risk of cardiovascular disease in 10-year survivors of breast cancer.
Journal of the National Cancer Institute 2007 Mar 07;99;365-75 2007 Mar 07

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