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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Chlorambucil

2

XV.l Path: Pulmonary fibrosis (not otherwise specified or unclassifiable)

1
Last update : 31/05/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Possible pulmonary effects of alkylating agents.
The New England journal of medicine 1972 Nov 30;287;1150-1 1972 Nov 30
Interstitial pulmonary fibrosis following busulfan therapy.
The American journal of medicine 1961 Jul;31;134-9 1961 Jul

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