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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Sulfadoxine

1

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

1
Last update : 13/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Sulfadoxine specific lymphocyte transformation in a patient with eosinophilic pneumonia induced by sulfadoxine-pyrimethamine (Fansidar).
Thorax 1989 Apr;44;307-9 1989 Apr
Fansidar hypersensitivity pneumonitis.
British journal of diseases of the chest 1987 Apr;81;194-6 1987 Apr
[Eosinophilic lung infiltration during malaria prophylaxis with pyrimethamine-sulfadoxine (Fansidar)].
Schweizerische medizinische Wochenschrift 1985 Aug 24;115;1174-6 1985 Aug 24
Unusual pulmonary reaction during short term prophylaxis with pyrimethamine-sulfadoxine (Fansidar).
British medical journal (Clinical research ed.) 1984 Jun 23;288;1876 1984 Jun 23
Serious reactions during malaria prophylaxis with pyrimethamine-sulfadoxine.
Lancet (London, England) 1982 Oct 30;2;994 1982 Oct 30

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