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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Capecitabine

2

XII.g Coronary artery disease (acute) - Myocardial ischemia/infarction

1
Last update : 08/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Capecitabine-Induced Coronary Vasospasm.
Case reports in oncology 2016;9;629-632 2016
Acute myocardial infarction after capecitabine treatment: not always vasospasm is responsible.
Chinese medical journal 2012 Sep;125;3349-51 2012 Sep
Capecitabine-induced chest pain relieved by diltiazem.
The American journal of cardiology 2012 Dec 01;110;1623-6 2012 Dec 01

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