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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Aspirin (Salicylate-ASA) - Aspirin containing drugs
5
II.b
ARDS - Acute lung injury
2
Last update :
28/05/2014
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Nonsteroidal anti-inflammatory drugs (NSAIDs)
Publications
Acute respiratory distress syndrome caused by salicylate intoxication.
Salicylate-induced pulmonary edema--a near-miss diagnosis.
Current management of salicylate-induced pulmonary edema.
Recurrent ARDS in a 39-year-old woman with migraine headaches.
Late diagnosis of chronic salicylate intoxication.
Acute salicylate self-poisoning in 177 consecutive patients treated in ICU.
Bronchoalveolar lavage in recurrent aspirin-induced adult respiratory distress syndrome.
Adult respiratory distress syndrome induced by salicylate toxicity.
Salicylate-induced pulmonary edema. Clinical features and prognosis.
Acute respiratory failure during therapy for salicylate intoxication.
Fatal respiratory-distress syndrome and salicylate intoxication in a two-year-old.