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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Pentazocine

2

VI.b Pulmonary arterial hypertension

1
Last update : 10/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Maternal death associated with intravenous methylphenidate (Ritalin) and pentazocine (Talwin) abuse.
Journal of forensic sciences 1987 May;32;798-801 1987 May
Transient pulmonary hypertension from the intravenous injection of crushed, suspended pentazocine tablets.
Chest 1981 Aug;80;178-82 1981 Aug
Pentazocine abuse. Report of a case with pulmonary arterial cellulose granulomas and pulmonary hypertension.
Chest 1980 Feb;77;227-30 1980 Feb

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