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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Pentazocine

2

VI.g Foreign body pulmonary vasculopathy (Excipient lung disease)

1
Last update : 21/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Pulmonary embolization of microcrystalline cellulose in a lung transplant recipient.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2005 May;24;624-7 2005 May
The effect of oral hydralazine on the pulmonary hemodynamics of patients with pulmonary foreign body granulomatosis.
Chest 1982 Dec;82;708-12 1982 Dec
Unusual pulmonary vascular lesions after intravenous injections of microcrystalline cellulose. A complication of pentazocine tablet abuse.
Virchows Archiv. A, Pathological anatomy and histology 1982;395;207-16 1982

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