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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Corticosteroids, inhaled (ICS)

5

XVII.g Tuberculosis (pulmonary, pulmonary, extrapulmonary or disseminated). Reactivation or de novo

2
Last update : 26/11/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Beclomethasone
2
Budesonide (inhaled)
3
Corticosteroids, systemic (oral, parenteral)
5
Fluticasone (inhaled - ICS)
4

Publications

Inhaled Corticosteroid-Related Tuberculosis in the Real World Among Patients with Asthma and COPD: A 10-Year Nationwide Population-Based Study.
The journal of allergy and clinical immunology. In practice 2019 Apr;7;1197-1206.e3 2019 Apr
Inhaled corticosteroids and the increased risk of pulmonary tuberculosis: a population-based case-control study.
International journal of clinical practice 2014 Oct;68;1193-9 2014 Oct
Use of inhaled corticosteroids in patients with COPD and the risk of TB and influenza: A systematic review and meta-analysis of randomized controlled trials. a systematic review and meta-analysis of randomized controlled trials.
Chest 2014 Jun;145;1286-1297 2014 Jun
Use of inhaled corticosteroids and the risk of tuberculosis.
Thorax 2013 Dec;68;1105-13 2013 Dec
Inhaled corticosteroid is associated with an increased risk of TB in patients with COPD.
Chest 2013 Apr;143;1018-1024 2013 Apr
Inhaled corticosteroids and risk of tuberculosis in patients with respiratory diseases.
American journal of respiratory and critical care medicine 2011 Mar 01;183;675-8 2011 Mar 01
Use of high-dose inhaled corticosteroids is associated with pulmonary tuberculosis in patients with chronic obstructive pulmonary disease.
Medicine 2010 Jan;89;53-61 2010 Jan

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