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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
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Corticosteroids, inhaled (ICS)
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VIII.j
Laryngeal disorder-Laryngeal nerve palsy (dysphonia, hoarseness)
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Last update :
11/09/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
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Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
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Causality assessment
More detailed checklist
See also under
Beclomethasone
Budesonide (inhaled)
Corticosteroids, systemic (oral, parenteral)
Fluticasone (inhaled - ICS)
Publications
Tracheobronchopathy From Inhaled Corticosteroids.
Voice evaluation in asthma patients using inhaled corticosteroids.
Dysphonia associated with the use of inhaled corticosteroids.
Practical considerations for dysphonia caused by inhaled corticosteroids.
Local oropharyngeal side effects of inhaled corticosteroids in patients with asthma.
Corticosteroid-induced laryngeal disorders in asthma.
Dysphonia caused by inhaled steroids: recognition of a characteristic laryngeal abnormality.
Administration of cortisone by the aerosol method in the treatment of bronchial asthma.