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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Alteplase (rTPA)

2

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

1
Last update : 10/05/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Angiotensin converting enzyme inhibitors (ACEI)
5
Tissue plasminogen activator (r-)
1

Publications

Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2000 May 02;162;1281-4 2000 May 02

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