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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Alteplase (rTPA)

2

V.e Hemothorax - Serosanguineous pleural effusion

1
Last update : 13/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Angiotensin converting enzyme inhibitors (ACEI)
5
Tissue plasminogen activator (r-)
1

Publications

Hemothorax under thrombolytic therapy with recombinant tissue: plasminogen activator (rt-PA) in a 16-year-old girl.
European journal of pediatrics 1999 Dec;158 Suppl 3;S140-2 1999 Dec

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