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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Carmustine (BCNU)

3

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

2
Last update : 29/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Bendamustine
1
Fotemustine
1
Lomustine (CCNU)
3
Nitrosoureas (suffixes '-NU', '-mustine')
4

Publications

Pulmonary toxicity following carmustine-based preparative regimens and autologous peripheral blood progenitor cell transplantation in hematological malignancies.
Bone marrow transplantation 2000 Feb;25;309-13 2000 Feb
Severe diffuse interstitial pneumonitis induced by carmustine (BCNU).
Chest 1994 May;105;1602-3 1994 May

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