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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Carmustine (BCNU)

3

II.b ARDS - Acute lung injury

2
Last update : 11/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Bendamustine
1
Fotemustine
1
Lomustine (CCNU)
3
Nitrosoureas (suffixes '-NU', '-mustine')
4

Publications

Efficacy and toxicity of a CCNU-containing high-dose chemotherapy regimen followed by autologous hematopoietic cell transplantation in relapsed or refractory Hodgkin's disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2001;7;552-60 2001
BCNU (1,3-bis-(2-chloroethyl)-1-nitrosurea) lung. Drug-induced pulmonary changes.
Cancer 1984 Aug 15;54;751-5 1984 Aug 15
Prediction of BCNU pulmonary toxicity in patients with malignant gliomas: an assessment of risk factors.
The New England journal of medicine 1980 Jul 24;303;183-8 1980 Jul 24
Irreversible pulmonary toxicity after single course of BCNU.
The American journal of the medical sciences 1980;279;53-6 1980
Pulmonary toxicity of bischloronitrosourea: report of a case with transient response to corticosteroid therapy.
Cancer 1979 May;43;1607-12 1979 May
Multiple pulmonary lesions in a patient treated with BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) for glioblastoma multiforme.
Cancer 1979 Jan;43;46-50 1979 Jan
Pulmonary toxicity from carmustine (BCNU): a case report.
Medical and pediatric oncology 1979;6;255-9 1979

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