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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Carbimazole

1

III.d Alveolar hemorrhage, diffuse (ANCA-positive/-related)

1
Last update : 10/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Carbimazole induced ANCA positive vasculitis.
The Journal of the Association of Physicians of India 2008 Oct;56;801-3 2008 Oct
Necrotizing glomerulonephritis and pulmonary hemorrhage associated with carbimazole therapy.
Thyroid : official journal of the American Thyroid Association 2005 Mar;15;286-8 2005 Mar

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