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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Benzodiazepines

5

VIII.c Upper airway obstruction other than angioedema or hematoma

2
Last update : 08/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Ethanol (ethyl alcohol, 'alcohol')
5
Midazolam
1

Publications

Mechanism of respiratory insufficiency in pure or mixed drug-induced coma involving benzodiazepines.
Journal of toxicology. Clinical toxicology 2002;40;35-47 2002
A risk for obstruction of the airways in the parenteral use of levomepromazine with benzodiazepine.
Pharmacopsychiatry 1998 Jul;31;126-30 1998 Jul

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