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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Ramipril

2

VIII.a Angioedema (may cause UAO, asphyxia and death)

2
Last update : 11/05/2015
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Fatal outcome of late-onset angiotensin-converting enzyme inhibitor induced angioedema: A case report.
Medicine 2018 Aug;97;e11695 2018 Aug
Allergic reaction related to ramipril use: a case report.
Diabetology & metabolic syndrome 2010 Jan 20;2;4 2010 Jan 20
Telmisartan, ramipril, or both in patients at high risk for vascular events.
The New England journal of medicine 2008 Apr 10;358;1547-59 2008 Apr 10
Angioedema from angiotensin-converting enzyme (ACE) inhibitor treated with complement 1 (C1) inhibitor concentrate.
Acta anaesthesiologica Scandinavica 2006 Jan;50;120-2 2006 Jan
Fresh frozen plasma in the treatment of resistant angiotensin-converting enzyme inhibitor angioedema.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2004 May;92;573-5 2004 May
[Tongue angioedema associated with angiotensin-converting enzyme inhibitor (diagnosis, differential diagnosis, treatment)].
Medicina (Kaunas, Lithuania) 2003;39;570-3 2003
Vasopeptidase inhibition and angio-oedema.
Lancet (London, England) 2000 Aug 19;356;608-9 2000 Aug 19

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