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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Captopril

4

VIII.a Angioedema (may cause UAO, asphyxia and death)

4
Last update : 10/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Images in clinical medicine. Angioedema of the tongue.
The New England journal of medicine 2006 Jul 20;355;295 2006 Jul 20
Simultaneous mucosal and small bowel angioedema due to captopril.
Southern medical journal 1998 Nov;91;1060-3 1998 Nov
Fatal angioedema associated with captopril.
Journal of forensic sciences 1992 Sep;37;1418-21 1992 Sep
Angioneurotic edema, agranulocytosis, and fatal septicemia following captopril therapy.
The American journal of medicine 1986 Aug;81;336-8 1986 Aug
Captopril-induced angioedema.
Annals of emergency medicine 1984 Jun;13;489-90 1984 Jun

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