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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Captopril
4
VIII.a
Angioedema (may cause UAO, asphyxia and death)
4
Last update :
10/07/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
Publications
Images in clinical medicine. Angioedema of the tongue.
Simultaneous mucosal and small bowel angioedema due to captopril.
Fatal angioedema associated with captopril.
Angioneurotic edema, agranulocytosis, and fatal septicemia following captopril therapy.
Captopril-induced angioedema.